Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• Κύριοι συγγραφείς: María Ailén Natale (Συγγραφέας), Todd Minning (Συγγραφέας), María Cecilia Albareda (Συγγραφέας), Melisa Daiana Castro Eiro (Συγγραφέας), María Gabriela Álvarez (Συγγραφέας), Bruno Lococo (Συγγραφέας), Gonzalo Cesar (Συγγραφέας), Graciela Bertocchi (Συγγραφέας), María Josefina Elias (Συγγραφέας), María Belén Caputo (Συγγραφέας), Rick Lee Tarleton (Συγγραφέας), Susana Adriana Laucella (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...