Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• Үндсэн зохиолчид: María Ailén Natale (Зохиогч), Todd Minning (Зохиогч), María Cecilia Albareda (Зохиогч), Melisa Daiana Castro Eiro (Зохиогч), María Gabriela Álvarez (Зохиогч), Bruno Lococo (Зохиогч), Gonzalo Cesar (Зохиогч), Graciela Bertocchi (Зохиогч), María Josefina Elias (Зохиогч), María Belén Caputo (Зохиогч), Rick Lee Tarleton (Зохиогч), Susana Adriana Laucella (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...