Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• Главные авторы: María Ailén Natale (Автор), Todd Minning (Автор), María Cecilia Albareda (Автор), Melisa Daiana Castro Eiro (Автор), María Gabriela Álvarez (Автор), Bruno Lococo (Автор), Gonzalo Cesar (Автор), Graciela Bertocchi (Автор), María Josefina Elias (Автор), María Belén Caputo (Автор), Rick Lee Tarleton (Автор), Susana Adriana Laucella (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Предметы: article
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In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...