Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice

• Main Authors: Nivedita Seshadri (Author), Michael E. Jonasson (Author), Kristin L. Hunt (Author), Bo Xiang (Author), Steven Cooper (Author), Michael B. Wheeler (Author), Vernon W. Dolinsky (Author), Christine A. Doucette (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); however, the physiological function of UCP2 in the β ce...