Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA

• Main Authors: Eva Schrom (Author), Maja Huber (Author), Manish Aneja (Author), Christian Dohmen (Author), Daniela Emrich (Author), Johannes Geiger (Author), Günther Hasenpusch (Author), Annika Herrmann-Janson (Author), Verena Kretzschmann (Author), Olga Mykhailyk (Author), Tamara Pasewald (Author), Prajakta Oak (Author), Anne Hilgendorff (Author), Dirk Wohlleber (Author), Heinz-Gerd Hoymann (Author), Dirk Schaudien (Author), Christian Plank (Author), Carsten Rudolph (Author), Rebekka Kubisch-Dohmen (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Changes in lifestyle and environmental conditions give rise to an increasing prevalence of liver and lung fibrosis, and both have a poor prognosis. Promising results have been reported for recombinant angiotensin-converting enzyme 2 (ACE2) protein administration in experimental liver and lung fibros...