Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

• Glavni autori: Martina Gentzsch (Autor), Deborah M. Cholon (Autor), Nancy L. Quinney (Autor), Mary E. B. Martino (Autor), John T. Minges (Autor), Susan E. Boyles (Autor), Tara N. Guhr Lee (Autor), Charles R. Esther (Autor), Carla M. P. Ribeiro (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The most common CFTR mutation, F508del, results in a pr...