Verification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients

• Main Authors: Era L. Pogosova-Agadjanyan (Author), Xing Hua (Author), Megan Othus (Author), Frederick R. Appelbaum (Author), Thomas R. Chauncey (Author), Harry P. Erba (Author), Matthew P. Fitzgibbon (Author), Isaac C. Jenkins (Author), Min Fang (Author), Stanley C. Lee (Author), Anna Moseley (Author), Jasmine Naru (Author), Jerald P. Radich (Author), Jenny L. Smith (Author), Brooke E. Willborg (Author), Cheryl L. Willman (Author), Feinan Wu (Author), Soheil Meshinchi (Author), Derek L. Stirewalt (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myeloid leukemia. We hypothesized that examining the homogenous leukemic bl...