High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions

• Main Authors: André Luiz Lourenço (Author), Shih-Wei Chuo (Author), Markus F. Bohn (Author), Byron Hann (Author), Shireen Khan (Author), Neha Yevalekar (Author), Nitin Patel (Author), Teddy Yang (Author), Lina Xu (Author), Dandan Lv (Author), Robert Drakas (Author), Sarah Lively (Author), Charles S. Craik (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe urokinase-type plasminogen activator receptor (uPAR) is an essential regulator for cell signaling in tumor cell proliferation, adhesion, and metastasis. The ubiquitous nature of uPAR in many aggressive cancer types makes uPAR an attractive target for immunotherapy. Here, we present a rap...