Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice

• Main Authors: Zhiwei Xue (Author), Lei Ye (Author), Jianwei Ge (Author), Zhen Lan (Author), Xinxin Zou (Author), Chenglu Mao (Author), Xinyu Bao (Author), Linjie Yu (Author), Yun Xu (Author), Xiaolei Zhu (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synaptic dysfunction plays a crucial role in the pathogenesis of Alzheimer's disease (AD). α/β-hydrolase domain-containing 6 (ABHD6) contributes to synaptic dysfunctions, and ABHD6 inhibition has shown potential therapeutic value in neurological disorders. However, the role of ABHD6 in AD has n...