Specific detection of high mobility group box 1 degradation product with a novel ELISA

• मुख्य लेखकों: Takaaki Totoki (लेखक), Takashi Ito (लेखक), Shingo Yamada (लेखक), Goichi Honda (लेखक), Tsuyoshi Hattori (लेखक), Ikuro Maruyama (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inflammation and remote organ failure. The proinflammatory effects of HMGB...