Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium

• Main Authors: Fátima Duarte Freire (Author), Manuela Bernardo Câmara (Author), Monique Gomes Dantas (Author), Cícero Flávio Soares Aragão (Author), Túlio Flávio Accioly de Lima e Moura (Author), Fernanda Nervo Raffin (Author)
• Format: Book
• Published: Universidade de São Paulo, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets...