High-throughput characterization of the role of non-B DNA motifs on promoter function

• Main Authors: Ilias Georgakopoulos-Soares (Author), Jesus Victorino (Author), Guillermo E. Parada (Author), Vikram Agarwal (Author), Jingjing Zhao (Author), Hei Yuen Wong (Author), Mubarak Ishaq Umar (Author), Orry Elor (Author), Allan Muhwezi (Author), Joon-Yong An (Author), Stephan J. Sanders (Author), Chun Kit Kwok (Author), Fumitaka Inoue (Author), Martin Hemberg (Author), Nadav Ahituv (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Alternative DNA conformations, termed non-B DNA structures, can affect transcription, but the underlying mechanisms and their functional impact have not been systematically characterized. Here, we used computational genomic analyses coupled with massively parallel reporter assays (MPRAs) to...