Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

• Main Authors: Matthew Riopel (Author), Jae-Su Moon (Author), Gautam K. Bandyopadhyay (Author), Seohee You (Author), Kevin Lam (Author), Xiao Liu (Author), Tatiana Kisseleva (Author), David Brenner (Author), Yun Sok Lee (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was designed to address this question. Method...