A lineage-tracing tool to map the fate of hypoxic tumour cells

• Main Authors: Jenny A. F. Vermeer (Author), Jonathan Ient (Author), Bostjan Markelc (Author), Jakob Kaeppler (Author), Lydie M. O. Barbeau (Author), Arjan J. Groot (Author), Ruth J. Muschel (Author), Marc A. Vooijs (Author)
• Format: Book
• Published: The Company of Biologists, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intratumoural hypoxia is a common characteristic of malignant treatment-resistant cancers. However, hypoxia-modification strategies for the clinic remain elusive. To date, little is known on the behaviour of individual hypoxic tumour cells in their microenvironment. To explore this issue in a spatia...