Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue

• Main Authors: Robin van Eenige (Author), Wietse In het Panhuis (Author), Milena Schönke (Author), Céline Jouffe (Author), Thomas H. Devilee (Author), Ricky Siebeler (Author), Trea C.M. Streefland (Author), Hetty C.M. Sips (Author), Amanda C.M. Pronk (Author), Ruben H.P. Vorderman (Author), Hailiang Mei (Author), Jan Bert van Klinken (Author), Michel van Weeghel (Author), Nina H. Uhlenhaut (Author), Sander Kersten (Author), Patrick C.N. Rensen (Author), Sander Kooijman (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity. Methods: RNA-sequencing, chroma...