Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina

• Main Authors: Yuka Kobayashi (Author), Shizuka Watanabe (Author), Agnes Lee Chen Ong (Author), Manabu Shirai (Author), Chiemi Yamashiro (Author), Tadahiko Ogata (Author), Fumiaki Higashijima (Author), Takuya Yoshimoto (Author), Takahide Hayano (Author), Yoshiyuki Asai (Author), Noriaki Sasai (Author), Kazuhiro Kimura (Author)
• Format: Book
• Published: The Company of Biologists, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinitis pigmentosa (RP) and macular dystrophy (MD) are characterized by gradual photoreceptor death in the retina and are often associated with genetic mutations, including those in the prominin-1 (Prom1) gene. Prom1-knockout (KO) mice recapitulate key features of these diseases including light-de...