Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7

• Principais autores: Ian H. Kimball (Autor), Phuong T. Nguyen (Autor), Baldomero M. Olivera (Autor), Jon T. Sack (Autor), Vladimir Yarov-Yarovoy (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The voltage-gated sodium (NaV) channel subtype NaV1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the molecular interactions between μ-Conotoxin KIIIA (KIIIA) and the human NaV1.7 channel (hNaV1.7). We developed a structural model of hNaV1.7 using Ros...