Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

• Main Authors: Yichang Zhao (Author), Huaiyuan Liu (Author), Chenlin Xiao (Author), Jingjing Hou (Author), Bikui Zhang (Author), Jiakai Li (Author), Min Zhang (Author), Yongfang Jiang (Author), Indy Sandaradura (Author), Xuansheng Ding (Author), Miao Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens are based on Monte Carlo simulation and has not...