Quantitation of tadalafil in human plasma using a sensitive and rapid LC-MS/MS method for a bioequivalence study

• Main Authors: Abhaysingh Bhadoriya (Author), Bhavesh Dasandi (Author), Dharmesh Parmar (Author), Priyanka A. Shah (Author), Pranav S. Shrivastav (Author)
• Formato: Livro
• Publicado em: Elsevier, 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of tadalafil (TAD) in human plasma. TAD and its deuterated internal standard (IS), tadalafil-d3, were extracted from 200 µL plasma using Phenomenex Strata-X-C 33 µ extraction cartr...