TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

• Main Authors: Stephen L. Rego (Author), Scott Harvey (Author), Sean R. Simpson (Author), Wayne O. Hemphill (Author), Zachariah A. McIver (Author), Jason M. Grayson (Author), Fred W. Perrino (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupu...