TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

• Hoofdauteurs: Stephen L. Rego (Auteur), Scott Harvey (Auteur), Sean R. Simpson (Auteur), Wayne O. Hemphill (Auteur), Zachariah A. McIver (Auteur), Jason M. Grayson (Auteur), Fred W. Perrino (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2018-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupu...