TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

• 主要な著者: Stephen L. Rego (著者), Scott Harvey (著者), Sean R. Simpson (著者), Wayne O. Hemphill (著者), Zachariah A. McIver (著者), Jason M. Grayson (著者), Fred W. Perrino (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupu...