The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

• Main Authors: Ravikumar A. Sitapara (Author), Alex G. Gauthier (Author), Vivek S. Patel (Author), Mosi Lin (Author), Michelle Zur (Author), Charles R. Ashby (Author), Lin L. Mantell (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia compromises the clearance of invading pathogens by...