The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

• Päätekijät: Ravikumar A. Sitapara (Tekijä), Alex G. Gauthier (Tekijä), Vivek S. Patel (Tekijä), Mosi Lin (Tekijä), Michelle Zur (Tekijä), Charles R. Ashby (Tekijä), Lin L. Mantell (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2020-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia compromises the clearance of invading pathogens by...