Involvement of Voltage-Gated Sodium Channel NaV1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons

• Main Authors: He-Bin Tang (Author), Eri Shiba (Author), Yu-Sang Li (Author), Norimitsu Morioka (Author), Tai-Xing Zheng (Author), Nobukuni Ogata (Author), Yoshihiro Nakata (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was conducted to determine whether Nav1.8 contributes to the release and/or synthesis of substance P (SP) in adult mice dorsal root ganglion (DRG) neurons. The SP released from cultured DRG neurons of Nav1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than th...