Involvement of intracellular cAMP in epirubicin-induced vascular endothelial cell injury

• Main Authors: Takaaki Yamada (Author), Mitsuyo Ueda (Author), Nobuaki Egashira (Author), Nina Zukeyama (Author), Jun Kuwahara (Author), Satohiro Masuda (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the involvement of intracellular cAMP in endothelial cell injury induced by epirubicin. Epirubicin-induced decrease in cell viability and increase in caspase-3/7 activity were reversed by a cAMP analog dibutyryl cAMP (DBcAMP) or an activator of adenylate cyclase forskolin concomitant...