The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families

• Κύριοι συγγραφείς: Shumail Syed (Συγγραφέας), Claudia Gragnoli (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: BMC, 2024-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Objectives Components of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome (PCOS). Impaired glucocorticoid receptor (NR3C1) expression and function may underlie impaired HPA-axis cortisol activity, thereby also contribut...