Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts

• Auteurs principaux: Amisha Sanghani (Auteur), Konstantinos N. Kafetzis (Auteur), Yusuke Sato (Auteur), Salsabil Elboraie (Auteur), Julia Fajardo-Sanchez (Auteur), Hideyoshi Harashima (Auteur), Aristides D. Tagalakis (Auteur), Cynthia Yu- (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The master regulator of the fibrosis cascade is the myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway, making it a key target for anti-fibrotic therapeutics. In the past, inhibitors and small interfering RNAs (siRNAs) targeting the <i>MRTF-B</i> gene have be...