Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts

• Main Authors: Amisha Sanghani (Author), Konstantinos N. Kafetzis (Author), Yusuke Sato (Author), Salsabil Elboraie (Author), Julia Fajardo-Sanchez (Author), Hideyoshi Harashima (Author), Aristides D. Tagalakis (Author), Cynthia Yu- (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The master regulator of the fibrosis cascade is the myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway, making it a key target for anti-fibrotic therapeutics. In the past, inhibitors and small interfering RNAs (siRNAs) targeting the <i>MRTF-B</i> gene have be...