Unraveling the Hippocampal Molecular and Cellular Alterations behind Tramadol and Tapentadol Neurobehavioral Toxicity

• Main Authors: Cristiana Soares-Cardoso (Author), Sandra Leal (Author), Susana I. Sá (Author), Rita Dantas-Barros (Author), Ricardo Jorge Dinis-Oliveira (Author), Juliana Faria (Author), Joana Barbosa (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol and tapentadol are chemically related opioids prescribed for the analgesia of moderate to severe pain. Although safer than classical opioids, they are associated with neurotoxicity and behavioral dysfunction, which arise as a concern, considering their central action and growing misuse and...