Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study

• Main Authors: Weiwei Jia (Author), Jing Li (Author), Feifei Du (Author), Yan Sun (Author), Fang Xu (Author), Fengqing Wang (Author), Olajide E. Olaleye (Author), Danghui Chen (Author), Wei Tang (Author), Jianping Zuo (Author), Chuan Li (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methyl (S)-4-(6-amino-9H-purin-9-yl)-2-hydroxybutanoate (DZ2002) is a potent reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH). Due to its ester structure, DZ2002 is rapidly hydrolyzed in rat blood to 4-(6-amino-9H-purin-9-yl)-2-hydroxybutyric acid (DZA) during and after blood sampl...