Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways

• Main Authors: Renyikun Yuan (Author), Qiumei Fan (Author), Xiaowei Liang (Author), Shan Han (Author), Jia He (Author), Qin-Qin Wang (Author), Hongwei Gao (Author), Yulin Feng (Author), Shilin Yang (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lung cancer is the leading cause of cancer mortality worldwide, and most of the patients after treatment with EGF-TKIs develop drug resistance, which is closely correlated with EMT. Cucurbitacin B (CuB) is a natural product of the Chinese herb Cucurbitaceae plant, which has a fav...