Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor

• Main Authors: Masayuki Nakano (Author), Motokazu Koga (Author), Tatsuo Hashimoto (Author), Natsuki Matsushita (Author), Daiki Masukawa (Author), Yusuke Mizuno (Author), Hiraku Uchimura (Author), Ryo Niikura (Author), Tomoyuki Miyazaki (Author), Fumio Nakamura (Author), Suo Zou (Author), Takahiro Shimizu (Author), Motoaki Saito (Author), Kouichi Tamura (Author), Takahisa Goto (Author), Yoshio Goshima (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary hypertension (PH) is a severe and progressive disease that causes elevated right ventricular systolic pressure, right ventricular hypertrophy and ultimately right heart failure. However, the underlying pathophysiologic mechanisms are poorly understood. We previously showed that 3,4-l-dihyd...