Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations

• Main Authors: Milica Markovic (Author), Arik Dahan (Author), Shahar Keinan (Author), Igor Kurnikov (Author), Aaron Aponick (Author), Ellen M. Zimmermann (Author), Shimon Ben-Shabat (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In ulcerative colitis (UC), the inflammation is localized in the colon, and one of the successful strategies for colon-targeting drug delivery is the prodrug approach. In this work, we present a novel phospholipid (PL)-based prodrug approach, as a tool for colonic drug targeting in UC. We aim to use...