Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition

• Main Authors: Aimin Yang (Author), Xia Xiao (Author), Mingfeng Zhao (Author), Amanda C. LaRue (Author), Bradley A. Schulte (Author), Gavin Y. Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal activation of the mammalian target of rapamycin (mTOR) signaling pathway has been observed in a variety of human cancers. Therefore, targeting of the mTOR pathway is an attractive strategy for cancer treatment and several mTOR inhibitors, including AZD8055 (AZD), a novel dual mTORC1/2 inhib...