Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition

• المؤلفون الرئيسيون: Aimin Yang (مؤلف), Xia Xiao (مؤلف), Mingfeng Zhao (مؤلف), Amanda C. LaRue (مؤلف), Bradley A. Schulte (مؤلف), Gavin Y. Wang (مؤلف)
• التنسيق: كتاب
• منشور في: Hindawi Limited, 2015-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abnormal activation of the mammalian target of rapamycin (mTOR) signaling pathway has been observed in a variety of human cancers. Therefore, targeting of the mTOR pathway is an attractive strategy for cancer treatment and several mTOR inhibitors, including AZD8055 (AZD), a novel dual mTORC1/2 inhib...