Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-Up

• मुख्य लेखकों: Beatrice Rivalta (लेखक), Donato Amodio (लेखक), Cinzia Milito (लेखक), Maria Chiriaco (लेखक), Silvia Di Cesare (लेखक), Carmela Giancotta (लेखक), Francesca Conti (लेखक), Veronica Santilli (लेखक), Lucia Pacillo (लेखक), Cristina Cifaldi (लेखक), Maria Giovanna Desimio (लेखक), Margherita Doria (लेखक), Isabella Quinti (लेखक), Rita De Vito (लेखक), Gigliola Di Matteo (लेखक), Andrea Finocchi (लेखक), Paolo Palma (लेखक), Antonino Trizzino (लेखक), Alberto Tommasini (लेखक), Caterina Cancrini (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Activated PI3K-kinase Delta Syndrome (APDS) is an autosomal-dominant primary immunodeficiency (PID) caused by the constitutive activation of the PI3Kδ kinase. The consequent hyperactivation of the PI3K-Akt-mTOR pathway leads to an impaired T- and B-cells differentiation and function, causing progres...