Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

• Main Authors: Xiao-Li Xiong (Author), Yan Ding (Author), Zhi-Lin Chen (Author), Yao Wang (Author), Pan Liu (Author), Huan Qin (Author), Li-Shan Zhou (Author), Ling-Ling Zhang (Author), Juan Huang (Author), Lei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis.MethodsCell and animal experiments were given diffe...