Evaluation of the cytochrome P450 2C19 and 3A4 inhibition potential of the complement factor 5a receptor 1 antagonist ACT‐1014‐6470 in vitro and in vivo

• 主要な著者: Marion Anliker‐Ort (著者), Jasper Dingemanse (著者), Stephane Delahaye (著者), Luboš Janů (著者), John van denAnker (著者), Benjamin Berger (著者), Priska Kaufmann (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2023-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract ACT‐1014‐6470 is an orally available complement factor 5a receptor 1 antagonist and a novel treatment option in auto‐inflammatory diseases. The in vitro inhibition potential of ACT‐1014‐6470 on cytochrome P450 isozymes (CYPs) and its effect on the pharmacokinetics (PK) of the CYP2C19 and CY...