Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure

• Main Authors: Erin Tay (Author), Tri-Hung Nguyen (Author), Leigh Ford (Author), Hywel D. Williams (Author), Hassan Benameur (Author), Peter J. Scammells (Author), Christopher J. H. Porter (Author)
• Format: Book
• Published: MDPI AG, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as low melting, lipophilic salts or ionic liquids (ILs...