Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

• Main Authors: Ana Paula S. Dornellas (Author), Giovana C. Macedo (Author), Minna H. McFarland (Author), Alexander Gómez-A (Author), Todd K. O'Buckley (Author), Claudio Da Cunha (Author), A. Leslie Morrow (Author), Donita L. Robinson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the nucleus accumbens and prefrontal cortex. As all...