The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

• Main Authors: Gaelle R. Carrat (Author), Elizabeth Haythorne (Author), Alejandra Tomas (Author), Leena Haataja (Author), Andreas Müller (Author), Peter Arvan (Author), Alexandra Piunti (Author), Kaiying Cheng (Author), Mutian Huang (Author), Timothy J. Pullen (Author), Eleni Georgiadou (Author), Theodoros Stylianides (Author), Nur Shabrina Amirruddin (Author), Victoria Salem (Author), Walter Distaso (Author), Andrew Cakebread (Author), Kate J. Heesom (Author), Philip A. Lewis (Author), David J. Hodson (Author), Linford J. Briant (Author), Annie C.H. Fung (Author), Richard B. Sessions (Author), Fabien Alpy (Author), Alice P.S. Kong (Author), Peter I. Benke (Author), Federico Torta (Author), Adrian Kee Keong Teo (Author), Isabelle Leclerc (Author), Michele Solimena (Author), Dale B. Wigley (Author), Guy A. Rutter (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the...