Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

• Egile Nagusiak: Tim Quach (Egilea), Luojuan Hu (Egilea), Sifei Han (Egilea), Shea F. Lim (Egilea), Danielle Senyschyn (Egilea), Preeti Yadav (Egilea), Natalie L. Trevaskis (Egilea), Jamie S. Simpson (Egilea), Christopher J. H. Porter (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism. Previous studies have shown that triglyceride (TG) mimetic prodrugs of the ster...