Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

• Main Authors: Li-Li Zou (Author), Fang-Ling Zhao (Author), Yu-Ying Qi (Author), Shuang-Hu Wang (Author), Quan Zhou (Author), Pei-Wu Geng (Author), Yun-Fang Zhou (Author), Qing Zhang (Author), Hao Chen (Author), Da-Peng Dai (Author), Jian-Ping Cai (Author), Fu-Sui Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic polymorphism of the cytochrome P450 (CYP) gene can significantly influence the metabolism of endogenous and xenobiotic compounds. However, few studies have focused on the polymorphism of CYP2J2 and its impact on drug catalytic activity, especially in the Chinese Han population. In this study...