Evaluation of Three-Dimensional Cultured HepG2 Cells in a Nano Culture Plate System: an In Vitro Human Model of Acetaminophen Hepatotoxicity

• Main Authors: Kohei Aritomi (Author), Yoichi Ishitsuka (Author), Yoshiro Tomishima (Author), Daisuke Shimizu (Author), Nazuki Abe (Author), Tsuyoshi Shuto (Author), Mitsuru Irikura (Author), Hirofumi Kai (Author), Tetsumi Irie (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overdoses of acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) cause severe liver injury, yet there is no common or high throughput in vitro human APAP model. This study examined the characteristics and usefulness of HepG2 cells grown in a nano culture plate (NCP) system, a three-dimensional...