Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity

• Главные авторы: Marina T. Varela (Автор), Maiara Romanelli (Автор), Maiara Amaral (Автор), Andre G. Tempone (Автор), João Paulo S. Fernandes (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-07-01T00:00:00Z.
• Предметы: article
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The absence of effective chronic treatment, expansion to non-endemic countries and the significant burden in public health have stimulated the search for novel therapeutic options to treat Chagas disease, a protozoan disease caused by Trypanosoma cruzi. Despite current efforts, no new drug candidate...