Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

• Main Authors: Haytham O. Tawfik (Author), Amany Belal (Author), Mohammed A. S. Abourehab (Author), Andrea Angeli (Author), Alessandro Bonardi (Author), Claudiu T. Supuran (Author), Mervat H. El-Hamamsy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully suppressed the hCA IX, with IC50 ranging from 28.6 to 871 nM. Compounds 5d, 11b, 5b, and 7b were the most active analogues, which in...