Ion channel regulation by phosphoinositides analyzed with VSPs - PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

• Main Authors: Alexandra eRjasanow (Author), Michael G. Leitner (Author), Veronika eThallmair (Author), Christian R Halaszovich (Author), Dominik eOliver (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P2. Yet, measuring...