Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

• Main Authors: Ioannis Temponeras (Author), Lykourgos Chiniadis (Author), Athanasios Papakyriakou (Author), Efstratios Stratikos (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2021-06-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation. Aiming to discover lead-like IRAP inhibitors with enhanced selectivity versus homolo...