A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line

• Main Authors: Xi Zhou (Author), Yunxiao Zhang (Author), Dongfang Tang (Author), Songping Liang (Author), Ping Chen (Author), Cheng Tang (Author), Zhonghua Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological studies. However, NaV1.8 expresses no or low-level...