Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway

• Main Authors: Binbin Hu (Author), Hanbo Zhang (Author), Menglu Xu (Author), Lei Li (Author), Man Wu (Author), Susu Zhang (Author), Xuejun Liu (Author), Weidong Xia (Author), Ke Xu (Author), Jian Xiao (Author), Hongyu Zhang (Author), Liyan Ni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although studies have shown that basic fibroblast growth factor (bFGF) can activate autophagy and promote peripheral nerve repair, the role and the molecular mechanism of action of bFGF in the facial nerve are not clear. In this study, a thermosensitive in situ forming poloxamer hydrogel was used as...