Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

• Main Authors: Cheng-Maw Ho (Author), Shu-Li Ho (Author), Yung-Ming Jeng (Author), Yu-Sheng Lai (Author), Ya-Hui Chen (Author), Shao-Chun Lu (Author), Hui-Ling Chen (Author), Po-Yuan Chang (Author), Rey-Heng Hu (Author), Po-Huang Lee (Author)
• Format: Book
• Published: BMC, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflamm...