Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound from HBV covalently closed circular (ccc)DNA. In addition, HBV DNA integrates in the human genome, serving as a source of hepatitis B surface antigen (HBsAg) expression,...

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Main Authors: Elena M. Smekalova (Author), Maria G. Martinez (Author), Emmanuel Combe (Author), Anuj Kumar (Author), Selam Dejene (Author), Dominique Leboeuf (Author), Chao-Ying Chen (Author), J. Robert Dorkin (Author), Lan Shuan Shuang (Author), Sarah Kieft (Author), Lauren Young (Author), Luis Alberto Barrera (Author), Michael S. Packer (Author), Giuseppe Ciaramella (Author), Barbara Testoni (Author), Francine Gregoire (Author), Fabien Zoulim (Author)
Format: Book
Published: Elsevier, 2024-03-01T00:00:00Z.
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