Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease

Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32,...

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Hoofdauteurs: Gaofeng Zhu (Auteur), Ping Bai (Auteur), Keren Wang (Auteur), Jing Mi (Auteur), Jing Yang (Auteur), Jiaqi Hu (Auteur), Yujuan Ban (Auteur), Ran Xu (Auteur), Rui Chen (Auteur), Changning Wang (Auteur), Lei Tang (Auteur), Zhipei Sang (Auteur)
Formaat: Boek
Gepubliceerd in: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Plaatsingsnummer: A1234.567
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