Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease
Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32,...
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Formaat: | Boek |
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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Internet
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Plaatsingsnummer: |
A1234.567 |
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Kopie 1 | Beschikbaar |