Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease

• Main Authors: Gaofeng Zhu (Author), Ping Bai (Author), Keren Wang (Author), Jing Mi (Author), Jing Yang (Author), Jiaqi Hu (Author), Yujuan Ban (Author), Ran Xu (Author), Rui Chen (Author), Changning Wang (Author), Lei Tang (Author), Zhipei Sang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32,...