Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogeni...

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Main Authors: Kathrin Pfeifer (Author), Georg Wolfstetter (Author), Vimala Anthonydhason (Author), Tafheem Masudi (Author), Badrul Arefin (Author), Mats Bemark (Author), Patricia Mendoza-Garcia (Author), Ruth H. Palmer (Author)
Format: Book
Published: The Company of Biologists, 2022-08-01T00:00:00Z.
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3rd Floor Main Library

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